From Washington, DC Lost River is two hours from I-66 West and the Capital Beltway. Take I-66 West to I-81 South (towards Roanoke). Take I-81 south for about 2 miles. Take exit 296. Take Route 55 West about 20 miles to Wardensville, WV. Turn left on Route 259 South. Follow Route 259 South about 10 miles to Baker. Turn left on Route 259 South and go 7 miles to Lost River. Look for signs. Bistro will be on right. From Harrisonburg, Virginia From I-81 North, take exit 257 (Timberville, Broadway). Take Route 259 West to Timberville. At the traffic light across from Broadway Motors, turn left (on 259 West). Follow Route 259 to West Virginia. Pass through Mathias, Lost City, and Lost River. Look for signs. Bistro will be on left. For more assistance, use MapQuest.